Practical Suggestion for Neuropixels Sorting

I have been asked multiple times about what is a good spike sorting algorithm for Neuropixels probes. I don’t usually have a great response and I was wondering what other people’s opinions were about this question. :slight_smile:

I think that the drift, high-density, and number of channels limits the number of useable algorithms to a few. My top candidates would be Kilosort2 and Ironclust since they are built for dealing with drift. However, is there a good python algorithm as well?